HB-EGF Is a Potent Inducer of Tumor Growth and Angiogenesis
Abstract
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been shown to stimulate the growth of a variety of cells in an autocrine or paracrine manner. Although HB-EGF is widely expressed in tumors compared with normal tissue, its contribution to tumorigenicity is unknown. HB-EGF can be produced as a membrane-anchored form (pro-HB-EGF) and later processed to a soluble form (s-HB-EGF), although a significant amount of pro-HB-EGF...
Paper Details
Title
HB-EGF Is a Potent Inducer of Tumor Growth and Angiogenesis
Published Date
Aug 1, 2004
Journal
Volume
64
Issue
15
Pages
5283 - 5290
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