Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226
Abstract
Neuropeptide FF (NPFF) is a part of a neurotransmitter system acting as a modulator of endogenous opioid functions. At this time, no non-peptide or peptide NPFF-antagonists have been discovered. Here, we demonstrate that Neuropeptide Y (NPY) ligands, in fact possess significant ability to interact with the human NPFF(2) receptors. NPY Y(1) antagonist BIBP3226 and mixed Y(1) antagonist/Y(4) agonist GR231118 are able to displace with low affinity,...
Paper Details
Title
Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226
Published Date
May 1, 2001
Volume
133
Issue
1
Pages
1 - 4
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