Interleukin-12 Is Expressed by Infiltrating Macrophages and Synovial Lining Cells in Rheumatoid Arthritis and Osteoarthritis
Abstract
TH1 cytokines have recently been detected in rheumatoid arthritis (RA) and osteoarthritis (OA). For this reason we studied the TH-1-promoting cytokine IL-12 in synovial membranes from patients with RA and OA. IL-12 transcripts and protein were analyzed by reverse transcriptase-polymerase chain reaction (PCR) and immunohistochemistry, respectively. In addition, IL-12 transcripts were quantitated by competitive PCR. IL-12 transcripts (p40) were...
Paper Details
Title
Interleukin-12 Is Expressed by Infiltrating Macrophages and Synovial Lining Cells in Rheumatoid Arthritis and Osteoarthritis
Published Date
Sep 1, 1998
Journal
Volume
188
Issue
2
Pages
105 - 110
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