Immunohistochemical expression of embryonic stem cell markers in malignant rhabdoid tumors.

Volume: 14, Issue: 5, Pages: 353 - 359
Published: Mar 21, 2011
Abstract
Malignant rhabdoid tumor is a highly aggressive pediatric neoplasm molecularly characterized by inactivating mutations of the SMARCB1 gene, a potent tumor suppressor and member of the SWI/SNF chromatin remodeling complex. It has been suggested that oncogenesis in SMARCB1-deficient cancers, such as malignant rhabdoid tumors, is driven not by the loss of SWI/SNF function but by an aberrant functioning of the BRG1-containing SWI/SNF complex. Since...
Paper Details
Title
Immunohistochemical expression of embryonic stem cell markers in malignant rhabdoid tumors.
Published Date
Mar 21, 2011
Volume
14
Issue
5
Pages
353 - 359
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