The Receptor for Advanced Glycation End Products (RAGE) Contributes to the Progression of Emphysema in Mice

Volume: 10, Issue: 3, Pages: e0118979 - e0118979
Published: Mar 17, 2015
Abstract
Several recent clinical studies have implied a role for the receptor for advanced glycation end products (RAGE) and its variants in chronic obstructive pulmonary disease (COPD). In this study we have defined a role for RAGE in the pathogenesis of emphysema in mice. RAGE deficient mice (RAGE-/-) exposed to chronic cigarette smoke were significantly protected from smoke induced emphysema as determined by airspace enlargement and had no significant...
Paper Details
Title
The Receptor for Advanced Glycation End Products (RAGE) Contributes to the Progression of Emphysema in Mice
Published Date
Mar 17, 2015
Journal
Volume
10
Issue
3
Pages
e0118979 - e0118979
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