Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance

Volume: 16, Issue: 12, Pages: 1414 - 1420
Published: Dec 1, 2010
Abstract
The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CRPC xenografts, we found a reproducible increase in N-cadherin expression, which was also elevated in primary and metastatic tumors of individuals with CRPC. Ectopic expression of N-cadherin in nonmetastatic, androgen-dependent prostate cancer models...
Paper Details
Title
Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance
Published Date
Dec 1, 2010
Volume
16
Issue
12
Pages
1414 - 1420
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.