Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance
Abstract
The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CRPC xenografts, we found a reproducible increase in N-cadherin expression, which was also elevated in primary and metastatic tumors of individuals with CRPC. Ectopic expression of N-cadherin in nonmetastatic, androgen-dependent prostate cancer models...
Paper Details
Title
Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance
Published Date
Dec 1, 2010
Journal
Volume
16
Issue
12
Pages
1414 - 1420
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