Unexpected low‐dose toxicity of the universal solvent DMSO
Abstract
Dimethyl sulfoxide (DMSO) is an important aprotic solvent that can solubilize a wide variety of otherwise poorly soluble polar and nonpolar molecules. This, coupled with its apparent low toxicity at concentrations <10%, has led to its ubiquitous use and widespread application. Here, we demonstrate that DMSO induces retinal apoptosis in vivo at low concentrations (5 μl intravitreally dosed DMSO in rat from a stock concentration of 1, 2, 4, and 8%...
Paper Details
Title
Unexpected low‐dose toxicity of the universal solvent DMSO
Published Date
Dec 10, 2013
Journal
Volume
28
Issue
3
Pages
1317 - 1330
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