Microstructural integrity of early- versus late-myelinating white matter tracts in medial temporal lobe epilepsy

Summary Purpose Patients with medial temporal lobe epilepsy ( MTLE ) exhibit structural brain damage involving gray matter ( GM ) and white matter ( WM ). The mechanisms underlying tissue loss in MTLE are unclear and may be associated with a combination of seizure excitotoxicity and WM vulnerability. The goal of this study was to investigate whether late‐myelinating WM tracts are more vulnerable to injury in MTLE compared with early myelinating...