Surface characterization and biocompatibility of micro- and nano-hydroxyapatite/chitosan-gelatin network films

Hydroxyapatite (HA)/polymer composites have been widely used in bone tissue engineering due to their chemical similarity to natural bone. And the surface characters of the composites are crucial to influence their biological properties. Here, nano-hydroxyapatite/chitosan-gelatin (nHCG) films were prepared via biomineralization of chitosan-gelatin (CG) network films in Ca(NO3)2-Na3PO4 Tris buffer solution at alkaline condition. And the...