Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody
Abstract
Angiopoietin-1 (Ang1) and its endothelium-specific receptor, tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2), play critical roles in vascular development. Although the Ang1/Tie2 system has been considered a promising target for therapeutic neovascularization, several imitations of large-scale production have hampered the development of recombinant Ang1 for therapeutics. In this study, we produced a fully human...
Paper Details
Title
Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody
Published Date
May 1, 2015
Journal
Volume
51
Pages
119 - 128
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