Solid tumour chemotherapy using implantable collagen-poly (HEMA) hydrogel containing 5-fluorouracil

Implantable collagen-poly(HEMA) hydrogels containing the anticancer drug 5-fluorouracil (5-FU) have been prepared and evaluated for their efficacy towards a solid tumour fibrosarcoma in Wistar rats. The tumour was developed by inoculation of a 10% tumour-cell suspension in the anterior aspect of the hind limb. Four groups were studied—untreated control, intratumoural injection of free 5-FU, subcutaneous implantation of placebo and implantation...