Renal mechanisms of salt-sensitive hypertension: contribution of two steroid receptor-associated pathways

Although salt is a major environmental factor in the development of hypertension, the degree of salt sensitivity varies widely among individuals. The mechanisms responsible for this variation remain to be elucidated. Recent studies have revealed the involvement of two important signaling pathways in renal tubules that play key roles in electrolyte balance and the maintenance of normal blood pressure: the β 2 -adrenergic stimulant-glucocorticoid...