Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system

Objective The major proteases responsible for aggrecan turnover in articular cartilage are the aggrecanases (ADAMTS‐4 and ADAMTS‐5). Although several studies have demonstrated C‐terminal truncation of these aggrecanases, the mechanism and importance of this processing are poorly understood. The objective of this study was to further investigate ADAMTS‐4 and ADAMTS‐5 C‐terminal truncation in a porcine model in vitro culture system. Methods...