Alzheimer Aβ peptide interactions with lipid membranes
Abstract
Fibrillar aggregates of misfolded amyloid proteins are involved in a variety of diseases such as Alzheimer disease (AD), type 2 diabetes, Parkinson, Huntington and prion-related diseases. In the case of AD amyloid β (Aβ) peptides, the toxicity of amyloid oligomers and larger fibrillar aggregates is related to perturbing the biological function of the adjacent cellular membrane. We used atomistic molecular dynamics (MD) simulations of Aβ9–40...
Paper Details
Title
Alzheimer Aβ peptide interactions with lipid membranes
Published Date
Sep 1, 2012
Journal
Volume
6
Issue
4
Pages
339 - 345
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History