Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation
Abstract
Poisoning via organophosphorus (OP) nerve agents occurs when the OP binds and inhibits the enzyme acetylcholinesterase (AChE). This enzyme is responsible for the metabolism of the neurotransmitter acetylcholine (ACh) which transmits signals between nerves and several key somatic regions. When AChE is inhibited, the signal initiated by ACh is not properly terminated. Excessive levels of ACh result in a cholinergic crisis, and in severe cases can...
Paper Details
Title
Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation
Published Date
Sep 1, 2010
Volume
187
Issue
1-3
Pages
229 - 233
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