Novel Mutation in the α-Myosin Heavy Chain Gene Is Associated With Sick Sinus Syndrome

Background— Recent genome-wide association studies have demonstrated an association between MYH6 , the gene encoding α-myosin heavy chain (α-MHC), and sinus node function in the general population. Moreover, a rare MYH6 variant, R721W, predisposing susceptibility to sick sinus syndrome has been identified. However, the existence of disease-causing MYH6 mutations for familial sick sinus syndrome and their underlying mechanisms remain unknown....