The synthesis and characterization of lipophilic peptide-based carriers for gene delivery

Volume: 66, Issue: 29, Pages: 5435 - 5441
Published: Jul 1, 2010
Abstract
Lipophilic carriers have shown great potential in improving the delivery of gene therapeutics. We have synthesized positively charged peptide-based carriers including lipoamino acids. The carriers were shown to interact with DNA by performing isothermal titration calorimetry and particle size and zeta potential experiments. An exothermic reaction resulted from the titration of carrier into DNA. The particle sizes of the carrier/DNA complexes...
Paper Details
Title
The synthesis and characterization of lipophilic peptide-based carriers for gene delivery
Published Date
Jul 1, 2010
Volume
66
Issue
29
Pages
5435 - 5441
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