Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3

Volume: 70, Issue: 20, Pages: 3973 - 3985
Published: Jun 2, 2013
Abstract
Affinity proteins based on small scaffolds are currently emerging as alternatives to antibodies for therapy. Similarly to antibodies, they can be engineered to have high affinity for specific proteins. A potential problem with small proteins and peptides is their short in vivo circulation time, which might limit the therapeutic efficacy. To circumvent this issue, we have engineered bispecificity into an albumin-binding domain (ABD) derived from...
Paper Details
Title
Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3
Published Date
Jun 2, 2013
Volume
70
Issue
20
Pages
3973 - 3985
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