Enhanced Serine Protease Activities in the Sulfur Mustard-Exposed Homogenates of Hairless Guinea Pig Skin
Abstract
Skin homogenates of hairless guinea pigs exposed percutaneously to sulfur mustard (SM) were investigated by measuring four serine protease activities (elastase, tryptase, chymase, and Asp-ase) using sensitive chromogenic substrates. The homogenate samples from skin area directly exposed to S M showed enhanced elastase activities. The tryptase (trypsin-like enzyme) activity also increased slightly; however, the chymase (chymotrypsin-like enzyme)...
Paper Details
Title
Enhanced Serine Protease Activities in the Sulfur Mustard-Exposed Homogenates of Hairless Guinea Pig Skin
Published Date
Nov 1, 1997
Volume
16
Issue
6
Pages
625 - 638
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