Interaction of Phytoestrogens with Estrogen Receptors α and β

Volume: 24, Issue: 4, Pages: 351 - 356
Published: Jan 1, 2002
Abstract
We investigated the estrogenic activities of isoflavone derivatives in competition binding assays with human estrogen receptor (hER) α or hER β protein, and in a gene expression assay using a yeast system. Coumestrol binds as strongly as 17β-estradiol to both hERs. Biochanin A, 5-OMe-genistein, formononetin, and tectorigenin bind well to hER β, but significant binding to hER α is only observed with 5-OMe-genistein, formononetin and tectorigenin....
Paper Details
Title
Interaction of Phytoestrogens with Estrogen Receptors α and β
Published Date
Jan 1, 2002
Volume
24
Issue
4
Pages
351 - 356
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