EGCG inhibits recepteur d’origine nantais expression by suppressing Egr-1 in gastric cancer cells

Abnormal accumulation and activation of the recepteur d'origine nantais (RON) has been implicated in epithelial tumor carcinogenesis. In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), the major green tea catechin, on the induction of RON and tumor growth in human gastric cancer. EGCG inhibited phorbol 12‑myristate 13‑acetate (PMA)‑induced RON expression and reduced RON transcriptional activity. However,...