Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing.

Published on Sep 14, 2010in Expert Opinion on Biological Therapy3.224
· DOI :10.1517/14712598.2010.515207
Lucília P. da Silva14
Estimated H-index: 14
(UC: University of Coimbra),
Eugenia Carvalho34
Estimated H-index: 34
(UC: University of Coimbra),
Maria Teresa Cruz31
Estimated H-index: 31
(UC: University of Coimbra)
Importance of the field: In 2010, the world prevalence of diabetes is 6.4%, affecting 285 million adults. Diabetic patients are at risk of developing neuropathy and delayed wound healing that can culminate in incurable diabetic foot ulcerations (DFUs) or even foot amputation.Areas covered in this review: The contrast between cellular and molecular events of wound healing and diabetic wound healing processes is characterized. Neuropeptides released from the autonomous nervous system and skin cells reveal a major role in the immunity of wound healing. Therefore, the signaling pathways that induce pro/anti-inflammatory cytokines expression and its involvement in diabetic wound healing are discussed. The involvement of neuropeptides in the activation, growth, migration and maturation of skin cells, like keratinocytes, Langerhans cells, macrophages and mast cells, are described.What the reader will gain: This review attempts to address the role of neuropeptides in skin inflammation, focusing on signal transduc...
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