Cyclosporine A, 2.5 mg/kg, Does Not Reduce Myocardial Infarct Size in a Porcine Model of Ischemia and Reperfusion

Volume: 17, Issue: 2, Pages: 159 - 163
Published: May 13, 2011
Abstract
Background: In recent years, cyclosporine A (CsA) has emerged as a promising therapy to limit myocardial ischemic–reperfusion injury, presumably by inhibiting the opening of the mitochondrial permeability transition pore. Results from different large animal models are conflicting, however, with failure to prove beneficial effects of 10 mg/kg CsA administered at reperfusion. Recently, a small clinical study using a bolus of 2.5 mg/kg CsA showed...
Paper Details
Title
Cyclosporine A, 2.5 mg/kg, Does Not Reduce Myocardial Infarct Size in a Porcine Model of Ischemia and Reperfusion
Published Date
May 13, 2011
Volume
17
Issue
2
Pages
159 - 163
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