Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics
Abstract
The mammalian ADAMTS superfamily comprises 19 secreted metalloproteinases and 7 ADAMTS-like proteins, each the product of a distinct gene. Thus far, all appear to be relevant to extracellular matrix function or to cell–matrix interactions. Most ADAMTS functions first emerged from analysis of spontaneous human and animal mutations and genetically engineered animals. The clinical manifestations of Mendelian disorders resulting from mutations in...
Paper Details
Title
Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics
Published Date
May 1, 2015
Journal
Volume
44-46
Pages
24 - 37
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