Delivering Multiparametric MRI-Guided High-Dose-Rate Brachytherapy Boost in Nonmetastatic Prostate Cancer

In localized prostate cancer, dominant intra-prostatic lesions (DiLs) of gross tumor are thought to drive metastatic potential. Tumour control and overall cancer control may be improved if DiLs are targeted with escalated radiation dose. This pilot study investigated the feasibility of focal high dose rate (HDR) brachytherapy boost in a cohort of patients treated with combined EBRT and HDR brachytherapy. Multi-parametric MRI (mp-MRI) was used...