Exercise Echocardiography in Rheumatoid Arthritis: A Case-Control Study

Published on Nov 1, 2009in Journal of The American Society of Echocardiography5.508
· DOI :10.1016/J.ECHO.2009.07.018
Mohammed K. Saghir2
Estimated H-index: 2
(Mayo Clinic),
Christine H. Attenhofer Jost11
Estimated H-index: 11
(Mayo Clinic)
+ 2 AuthorsPatricia A. Pellikka101
Estimated H-index: 101
(Mayo Clinic)
Background Rheumatoid arthritis (RA) is associated with increased cardiovascular risk. Methods To assess the role of exercise echocardiography (EE) in the evaluation of patients with RA, follow-up (mean, 6.7±3.7 years) was retrospectively obtained in 159 patients with RA who underwent EE. Patients were matched for age, gender, and cardiovascular risk factors with 454 controls who underwent EE. Results Patients with RA were more likely to have positive results for ischemia on EE (odds ratio, 2.32; 95% confidence interval, 1.48-3.64; P =.0003). Rest and exercise wall motion score indexes were higher in the RA group (1.14±0.33 and 1.22±0.39, respectively, vs 1.06±0.18 and 1.10±0.24 in controls; P P =.005) per year of RA. Five-year all-cause mortality in subjects with RA with myocardial ischemia on EE was 14.9%, compared with 4.3% in RA subjects without ischemia ( P =.028). Conclusion RA was associated with a 2-fold increased risk for myocardial ischemia on EE; risk increased with the duration of RA. Mortality was increased in patients with RA with ischemia on EE.
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