Genotyping in Prothrombotic States: Implications for the Clinician

Thrombophilia has been subject to extensive genetic research. This review focuses on the genetic variants that have confirmed associations with venous thrombosis (VT). For incident VT, the early discovery of variants with large-magnitude associations, such as mutations in antithrombin, protein C, and protein S genes, has been followed by genetic variants that are associated with more moderate risk, such as the factor V Leiden, and prothrombin...