Development of a screening assay to evaluate the potential of drugs to cause immune-mediated hypersensitivity reactions
Abstract
Evidence suggests that bio-activation of drugs to generate chemically reactive metabolites (RM) that act as haptens to form immunogenic protein conjugates may be an important cause of immune-mediated drug hypersensitivity reactions (IDHR). Although many drugs that form RMs raise concerns about producing IDHR, standard non-clinical testing methods are rarely able to identify compounds with the potential to produce IDHR in humans. The objective of...
Paper Details
Title
Development of a screening assay to evaluate the potential of drugs to cause immune-mediated hypersensitivity reactions
Published Date
Jun 14, 2013
Journal
Volume
11
Issue
2
Pages
110 - 115
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History