Canine Oral Papillomavirus Genomic Sequence: A Unique 1.5-kb Intervening Sequence between the E2 and L2 Open Reading Frames

The canine oral papillomavirus (COPV) is associated with oropharyneal papillomatosis in dogs, coyotes, and wolves. We have determined the complete nucleotide sequence of COPV, the largest of all known PV genomes (8607 bp). The genomic architecture of the COPV genome is similar to that of other PVs except for a unique and large noncoding region of 1.6 kb between the end of the early region (E2) and the beginning of the late region (L2) and a...