Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry
Abstract
An advanced two-dimensional liquid chromatography/mass spectrometry platform was used to quantify individual host cell proteins (HCPs) present at various purification steps for several therapeutic monoclonal antibodies (mAbs) produced in Chinese hamster ovary cells. The methodology produced reproducible identifications and quantifications among replicate analyses consistent with a previously documented individual limit of quantification of ~13...
Paper Details
Title
Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry
Published Date
Feb 11, 2014
Journal
Volume
6
Issue
3
Pages
659 - 670
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Notes
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