TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2

Volume: 5, Issue: 1, Pages: 4994 - 4994
Published: Sep 26, 2014
Abstract
Mutations in the ankyrin repeat domain (ARD) of TRPV4 are responsible for several channelopathies, including Charcot-Marie-Tooth disease type 2C and congenital distal and scapuloperoneal spinal muscular atrophy. However, the molecular pathogenesis mediated by these mutations remains elusive, mainly due to limited understanding of the TRPV4 ARD function. Here we show that phosphoinositide binding to the TRPV4 ARD leads to suppression of the...
Paper Details
Title
TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2
Published Date
Sep 26, 2014
Volume
5
Issue
1
Pages
4994 - 4994
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