Quantification with a dedicated breast PET/CT scanner

Published on May 1, 2012in Medical Physics3.317
· DOI :10.1118/1.3703593
Spencer L. Bowen11
Estimated H-index: 11
(Harvard University),
Andrea Ferrero8
Estimated H-index: 8
(UC Davis: University of California, Davis),
Ramsey D. Badawi29
Estimated H-index: 29
(UC Davis: University of California, Davis)
Purpose: Dedicated breast PET/CT is expected to have utility in local staging, surgical planning, monitoring of therapy response, and detection of residual disease for breast cancer. Quantitative metrics will be integral to several such applications. The authors present a validation of fully 3D data correction schemes for a custom built dedicated breast PET/CT (DbPET/CT) scanner via 18F-FDG phantom scans. Methods: A component-based normalization was implemented, live-time was estimated with a multicomponent model, and a variance reduced randoms estimate was computed from delayed coincidences. Attenuation factors were calculated by using a CT based segmentation scheme while scatter was computed using a Monte Carlo (MC) simulation method. As no performance standard currently exists for breast PET systems, custom performance tests were created based on prior patient imaging results. Count-rate linearity for live-time and randoms corrections was measured with a decay experiment for a solid polyethylene cylinder phantom with an offset line source. A MC simulation was used to validate attenuation correction, a multicompartment phantom with asymmetric activity distribution provided an assessment of scatter correction, and image uniformity after geometric and detector normalization was measured from a high count scan of a uniform cylinder phantom. Raw data were reconstructed with filtered back projection (FBP) after Fourier rebinning. To quantify performance absolute activity concentrations, contrast recovery coefficients and image uniformity were calculated through region of interest analysis. Results: The most significant source of error was attributed to mispositioning of events due to pile-up, presenting in count-related axial and transaxial nonuniformities that were not corrected for with the normalization method used here. Within the range of singles counts observed during clinical trials residual error after applying all corrections was comparable to that of a commercial whole body PET/CT system. Conclusions: The results suggest that DbPET/CT is capable of producing quantitative images under the operating conditions expected during patient imaging.
📖 Papers frequently viewed together
121 Citations
80 Citations
47 Citations
#1Nicholas A. Shkumat (University of Texas MD Anderson Cancer Center)H-Index: 1
#2Adam Springer (University of Texas MD Anderson Cancer Center)H-Index: 2
Last. Osama MawlawiH-Index: 34
view all 11 authors...
Purpose: A new positron emission mammography(PEM) device (PEM Flex Solo II, Naviscan Inc., San Diego, CA) has recently been introduced and its performance characteristics have been documented. However, no systematic assessment of its limit of detectability has been evaluated. The aim of this work is to investigate the limit of detectability of this new PEMsystem using a novel, customized breast phantom. Methods: Two sets of F-18 infused gelatin breast phantoms of varying thicknesses (2, 4, 6, an...
12 CitationsSource
Summary Introduction: The goal of this initial clinical study was to test a new positron emission/tomography imager and biopsy system (PEM/PET) in a small group of selected subjects to assess its clinical imaging capabilities. Specifically, the main task of this study is to determine whether the new system can successfully be used to produce images of known breast cancer and compare them to those acquired by standard techniques. Methods: The PEM/PET system consists of two pairs of rotating radia...
27 CitationsSource
#1Nicolas D. Prionas (UC Davis: University of California, Davis)H-Index: 10
#2Karen K. Lindfors (UC Davis: University of California, Davis)H-Index: 38
Last. John M. Boone (UC Davis: University of California, Davis)H-Index: 74
view all 7 authors...
Conspicuity of malignant breast masses at contrast-enhanced breast CT is significantly better than that at mammography or unenhanced breast CT, whereas conspicuity of lesions associated with malignant calcifications is better at contrast-enhanced breast CT than at unenhanced breast CT and is similar at contrast-enhanced breast CT and mammography.
146 CitationsSource
#1Yuji Nakamoto (Kyoto University)H-Index: 58
#2Koichi Ishizu (Kyoto University)H-Index: 26
Last. Kaori Togashi (Kyoto University)H-Index: 84
view all 5 authors...
2 Citations
The recently published NEMA NU 4-2008 Standards has been specially designed for evaluating the performance of small animal PET scanners used in preclinical applications. In this paper, we report on the NU 4 performance of a clinical positron emission mammography (PEM) system. Since there are no PEM specific performance test protocols available, and the NU 2 protocol (intended for whole-body PET scanners) cannot be applied without modification due to the compact design of the PEM scanner, we deci...
41 CitationsSource
#1John M. Boone (UC Davis: University of California, Davis)H-Index: 74
#2Kai Yang (UC Davis: University of California, Davis)H-Index: 23
Last. Karen K. Lindfors (UC Davis: University of California, Davis)H-Index: 38
view all 8 authors...
Mammography has served the population of women who are at-risk for breast cancer well over the past 30 years. While mammography has undergone a number of changes as digital detector technology has advanced, other modalities such as computed tomography have experienced technological sophistication over this same time frame as well. The advent of large field of view flat panel detector systems enable the development of breast CT and several other niche CT applications, which rely on cone beam geom...
16 CitationsSource
#1Masafumi Furuta (Shimadzu Corp.)H-Index: 5
#2Keishi Kitamura (Shimadzu Corp.)H-Index: 18
Last. Yoshihiko Kumazawa (Shimadzu Corp.)H-Index: 6
view all 13 authors...
For diagnosis of very small lesions of breast cancer on very early stage, a dedicated breast positron emission tomography (PET) scanner consisting of four-layer depth of interaction (DOI) detectors is now under development. We are aiming for the spatial resolution of less than 1 mm across a large effective field of view (FOV), and acquisition time of less than 5 minutes for each breast and 10 minutes in total. The "C" shape of this scanner allows it to be positioned closely around the breast, ef...
33 CitationsSource
#1Lawrence R. MacDonald (UW: University of Washington)H-Index: 16
#2John EdwardsH-Index: 2
Last. Paul E. Kinahan (UW: University of Washington)H-Index: 69
view all 6 authors...
Positron emission mammography (PEM) is a technique using 2 annihilation-photon detectors and limited-angle tomographic reconstruction to image radiotracer distributions within the breast. Because of their smaller size and closer proximity to the source, dedicated PEM cameras can provide better spatial resolution and count sensitivity than whole-body PET (WB PET). PEM is undergoing clinical trials and has been suggested for breast cancer detection, characterization, treatment planning, and assess...
121 CitationsSource
#1Spencer L. Bowen (UC Davis: University of California, Davis)H-Index: 11
#2Yibao Wu (UC Davis: University of California, Davis)H-Index: 17
Last. Ramsey D. BadawiH-Index: 29
view all 16 authors...
Whole-body (WB) 18F-FDG PET has clinical utility in breast cancer staging, restaging, and therapy response assessment. A study by Rousseau et al. (1) found that WB PET could identify tumors with pathologic response after a single course of neoadjuvant chemotherapy (sensitivity, 61%; specificity, 96%), whereas mammography had limited accuracy (sensitivity, 31%; specificity, 56%), even after 6 courses of treatment. WB PET has been shown to have a high accuracy for detecting distant metastasis. Mah...
102 CitationsSource
#1Yibao Wu (UC Davis: University of California, Davis)H-Index: 17
#2Spencer L. Bowen (UC Davis: University of California, Davis)H-Index: 11
Last. Ramsey D. Badawi (UC Davis: University of California, Davis)H-Index: 29
view all 10 authors...
A dedicated breast PET/CT system has been constructed at our institution, with the goal of having increased spatial resolution and sensitivity compared to whole-body systems. The purpose of this work is to describe the design and the performance characteristics of the PET component of this device. Average spatial resolution of a line source in warm background using maximum a posteriori (MAP) reconstruction was 2.5 mm, while the average spatial resolution of a phantom containing point sources usi...
47 CitationsSource
Cited By11
#1Abhijit J. Chaudhari (UC Davis: University of California, Davis)H-Index: 18
#2Ramsey D. Badawi (UC Davis: University of California, Davis)H-Index: 29
Nuclear medical imaging devices, such as those enabling photon emission imaging (gamma camera, single photon emission computed tomography (SPECT), or positron emission imaging (PET)), that are typically used in today's clinics are optimized for assessing large portions of the human body, and are classified as whole-body imaging systems. These systems have known limitations for organ imaging, therefore application-specific devices have been designed, constructed and evaluated. These devices, give...
#1S. Krishnamoorthy (UPenn: University of Pennsylvania)H-Index: 14
#2Trevor L. Vent (UPenn: University of Pennsylvania)H-Index: 5
Last. Suleman Surti (UPenn: University of Pennsylvania)H-Index: 32
view all 6 authors...
We are developing a dedicated, combined breast PET-tomosynthesis scanner. Both the PET and digital breast tomosynthesis (DBT) scanners are integrated in a single gantry to provide spatially co-registered 3D PET-tomosynthesis images. The DBT image will be used to identify the breast boundary and breast density to improve the quantitative accuracy of the PET image. This paper explores PET attenuation correction (AC) strategies that can be performed with the combined breast PET-DBT scanner to obtai...
#1Jianyong Jiang (WashU: Washington University in St. Louis)H-Index: 3
#2Suranjana Samanta (WashU: Washington University in St. Louis)H-Index: 1
Last. Yuan-Chuan TaiH-Index: 24
view all 10 authors...
A novel technique, called augmented whole-body scanning via magnifying PET (AWSM-PET), that improves the sensitivity and lesion detectability of a PET scanner for whole-body imaging is proposed and evaluated. A Siemens Biograph Vision PET/CT scanner equipped with one or two high-resolution panel-detectors was simulated to study the effectiveness of AWSM-PET technology. The detector panels are located immediately outside the scanner's axial field-of-view (FOV). A detector panel contains 2 x 8 det...
We investigated PET image quantification when using a uniform attenuation coefficient ( \mu ) for attenuation correction (AC) of anthropomorphic density phantoms derived from high-resolution breast CT scans. A breast PET system was modeled with perfect data corrections except for AC. Using uniform \mu for AC resulted in quantitative errors roughly proportional to the difference between \mu used in AC ( \mu _{\mathrm{ AC}}) and local \mu , yielding approximately ± 5% bias, correspo...
3 CitationsSource
#1Lawrence R. MacDonald (UW: University of Washington)H-Index: 16
#2William J. Hunter (UW: University of Washington)H-Index: 3
Last. Paul E. Kinahan (UW: University of Washington)H-Index: 69
view all 8 authors...
We are currently building the PET/X scanner, which is a breast positron emission tomography (PET) scanner combined with a standard X-ray mammography system. The role for the PET/X scanner is to precisely measure changes in radiotracer uptake after an initial test dose of adjuvant or neoadjuvant therapy. The system performance target is that a measured 20% change in tracer uptake in 5 mm diameter lesions with standardized uptake value (SUV) of 5 g/ml should correspond to at least 95% specificity ...
3 CitationsSource
#1Raymond R. Raylman (WVU: West Virginia University)H-Index: 27
#2Will Van KampenH-Index: 1
Last. Mark PernaH-Index: 1
view all 10 authors...
PURPOSE: Application of advanced imaging techniques, such as PET and x ray CT, can potentially improve detection of breast cancer. Unfortunately, both modalities have challenges in the detection of some lesions. The combination of the two techniques, however, could potentially lead to an overall improvement in diagnostic breast imaging. The purpose of this investigation is to test the basic performance of a new dedicated breast-PET/CT. METHODS: The PET component consists of a rotating pair of de...
7 CitationsSource
#1Chengeng Zeng (UW: University of Washington)H-Index: 2
#2Paul E. Kinahan (UW: University of Washington)H-Index: 69
Last. Lawrence R. MacDonald (UW: University of Washington)H-Index: 16
view all 6 authors...
The goal for positron emission tomography (PET)/X is measuring changes in radiotracer uptake for early assessment of response to breast cancer therapy. Upper bounds for detecting such changes were investigated using simulation and two image reconstruction algorithms customized to the PET/X rectangular geometry. Analytical reconstruction was used to study spatial resolution, comparing results with the distance of the closest approach (DCA) resolution surrogate that is independent of the reconstru...
2 CitationsSource
#1David L. Freese (Stanford University)H-Index: 4
#2David Hsu (Stanford University)H-Index: 49
Last. Craig S. Levin (Stanford University)H-Index: 36
view all 4 authors...
We are constructing a 1 mm ^{3}resolution, clinical PET system dedicated to locoregional cancer imaging, focusing primarily on the breast as well as the head and neck regions. The two-panel system comprises 98,304 1x1x0.9 mm LYSO crystals, for a total of 2.4 \times 10 ^{9}LORs, thus, it is impractical to gather even a low number of statistics per LOR for normalization. Based upon LOR symmetry, we combine our 2.4 \times 10 ^{9}LORs into 3.25 \times 10 ^{6}symmetric LORs (SLORs). We si...
#1Abhijit J. Chaudhari (UC Davis: University of California, Davis)H-Index: 18
#2Andrea Ferrero (UC Davis: University of California, Davis)H-Index: 8
Last. Ramsey D. Badawi (UC Davis: University of California, Davis)H-Index: 29
view all 10 authors...
Objective:Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) commonly affect the small joints of the wrist and hand. We evaluated the performance of a new, high-resolution extremity positron emission tomography (PET)/CT scanner for characterizing and quantifying pathologies associated with the two arthritides in the wrist and hand joints.Methods:Patients with RA or PsA underwent fluorine-18 fludeoxyglucose (18F-FDG) PET/CT wrist and hand imaging, respectively, on the high-resolution scanner...
25 CitationsSource
#1David F. C. Hsu (Stanford University)H-Index: 2
#2David L. Freese (Stanford University)H-Index: 4
Last. Craig S. Levin (Stanford University)H-Index: 36
view all 3 authors...
: Breast-dedicated radionuclide imaging systems show promise for increasing clinical sensitivity for breast cancer while minimizing patient dose and cost. We present several breast-dedicated coincidence-photon and single-photon camera designs that have been described in the literature and examine their intrinsic performance, clinical relevance, and impact. Recent tracer development is mentioned, results from recent clinical tests are summarized, and potential areas for improvement are highlighte...
20 CitationsSource