Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment
Abstract
Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Dll4 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is mediated either by direct cell-cell contact or by Dll4-containing exosomes from a distance. However, whether Dll4-containing exosomes influence tip...
Paper Details
Title
Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment
Published Date
Feb 7, 2014
Journal
Volume
4
Issue
1
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