Particle engineering using sonocrystallization: Salbutamol sulphate for pulmonary delivery
Volume: 368, Issue: 1-2, Pages: 129 - 137
Published: Feb 1, 2009
Abstract
The aim of present work was to produce fine elongated crystals of salbutamol sulphate (SS) by sonocrystallization for pulmonary delivery and compare with micronized and spray dried SS (SDSS) for in vitro aerosolization behavior. Application of ultrasound during anti-solvent crystallization resulted in fine elongated crystals (sonocrystallized SS; SCSS) compared to aggregates of large irregular crystals obtained without sonication. Higher...
Paper Details
Title
Particle engineering using sonocrystallization: Salbutamol sulphate for pulmonary delivery
Published Date
Feb 1, 2009
Volume
368
Issue
1-2
Pages
129 - 137
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