Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis
Abstract
In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because of the action of angiogenic inhibitors that prevent vessels from invading the cornea and vitreous. Here, an inhibitor responsible for the avascularity of these ocular compartments is identified as pigment epithelium–derived factor (PEDF), a protein previously shown to have neurotrophic activity. The amount of inhibitory PEDF produced by retinal cells...
Paper Details
Title
Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis
Published Date
Jul 9, 1999
Journal
Volume
285
Issue
5425
Pages
245 - 248
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