Abstract A59: Increased expression of ABC transporter genes in lung cancer CD133‐positive cells

Drug resistance represents a major obstacle towards the cure of different tumor types including non-small cell lung cancer (NSCLC), being one of the main causes of failure of antitumor therapy. Tumor cells frequently exhibit simultaneous resistance to multiple structurally unrelated drugs, a phenotype known as multidrug resistance (MDR). A major cause of the MDR phenotype is the over-expression of members of a conserved family of transmembrane...