Embracing Phenomenological Approaches to Normal Tissue Complication Probability Modeling: A Question of Method

In the field of normal tissue complication probability (NTCP) modeling, it is common practice to build models using a combination of biological knowledge and clinical data. Currently, in attempts to increase the accuracy of these models, it is often presumed that complications are caused by a multitude of factors, of which adequate biological descriptions may be lacking, but that can be inferred from clinical, dosimetry, or genetic data. Thus,...