TAM receptor signaling and autoimmune disease
Abstract
The TAM receptor tyrosine kinases Tyro3, Axl, and Mer and their ligands Gas6 and Protein S are essential for the phagocytosis of apoptotic cells and membranes in the adult immune, nervous, and reproductive systems. Genetic studies indicate that this receptor-ligand system is central to apoptotic cell engulfment that is triggered by the 'eat-me' signal phosphatidylserine (PtdSer). At the same time, TAM signaling is normally activated by Toll-like...
Paper Details
Title
TAM receptor signaling and autoimmune disease
Published Date
Dec 1, 2010
Volume
22
Issue
6
Pages
740 - 746
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