Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation
Abstract
Clonidine is approved for spinal administration against neuropathic pain, and reverses both spontaneous and elicited pain in humans following spinal administration. Rodent studies that seek to model pharmacology in pain states have historically relied on reflexive withdrawal from noxious stimuli as the primary endpoint. Drug self-administration studies have face validity in the drug abuse field for modeling drug abuse in humans, however, this...
Paper Details
Title
Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation
Published Date
Dec 1, 2006
Journal
Volume
125
Issue
3
Pages
257 - 263
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