Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier
Abstract
Inhaled gene carriers must penetrate the highly viscoelastic and adhesive mucus barrier in the airway in order to overcome rapid mucociliary clearance and reach the underlying epithelium; however, even the most widely used viral gene carriers are unable to efficiently do so. We developed two polymeric gene carriers that compact plasmid DNA into small and highly stable nanoparticles with dense polyethylene glycol (PEG) surface coatings. These...
Paper Details
Title
Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier
Published Date
Mar 1, 2014
Volume
178
Pages
8 - 17
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