Lack of clopidogrel-CYP3A4 statin interaction in patients with acute coronary syndrome

To assess a clinically significant interaction between cytochrome P450 3A4 (CYP3A4) metabolised statin and clopidogrel.Prospective single centre cohort study.Academic teaching hospital in the USA.1651 patients presenting with acute coronary syndromes between January 1999 and February 2003 were studied. Data on baseline demographics, co-morbidities, and in-hospital management were collected.Association of CYP3A4 metabolised statin and clopidogrel...