Metabolic Inhibition as an Index of Bacterial Susceptibility to Drugs

Detection of bacterial growth by measuring the release of 14 CO 2 from the metabolism of uniformly labeled 14 C-glucose has proven to be accurate, sensitive, and rapid. The inhibition of glucose metabolism by antibiotics as an index of bacterial susceptibility was evaluated based on radiometric methodology. Bacterial dose-response curves to antibiotics were defined. The susceptibility to drugs was determined within several hours after...