Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy
Abstract
Oncolytic replication-selective adenoviruses constitute a rapidly expanding experimental approach to the treatment of cancer. However, due to the lack of an immunocompetent and replication-competent efficacy model, the role of the host immune response and viral E3 immunoregulatory genes remained unknown. We screened nine murine carcinoma lines for adenovirus (Ad5) uptake, gene expression, replication, and cytopathic effects. In seven of these...
Paper Details
Title
Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy
Published Date
Sep 1, 2003
Journal
Volume
8
Issue
3
Pages
412 - 424
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