Requirement of Interaction between Mast Cells and Skin Dendritic Cells to Establish Contact Hypersensitivity
Abstract
The role of mast cells (MCs) in contact hypersensitivity (CHS) remains controversial. This is due in part to the use of the MC-deficient Kit (W/Wv) mouse model, since Kit (W/Wv) mice congenitally lack other types of cells as a result of a point mutation in c-kit. A recent study indicated that the intronic enhancer (IE) for Il4 gene transcription is essential for MCs but not in other cell types. The aim of this study is to re-evaluate the roles...
Paper Details
Title
Requirement of Interaction between Mast Cells and Skin Dendritic Cells to Establish Contact Hypersensitivity
Published Date
Sep 30, 2011
Journal
Volume
6
Issue
9
Pages
e25538 - e25538
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