Abstract 3287: Pro-inflammatory factors secreted by pancreatic cancers with evasive resistance to anti-VEGF treatment contribute to malignant progression by inducing EMT

Background: Resistance of tumors to anti-angiogenic therapies is becoming an increasingly relevant issue. Moreover, recent studies provided evidences that VEGF-targeted drugs could make tumor cells more aggressive and metastatic. Methods: To identify the tumor-derived factors responsible for the evasive resistance of pancreatic cancer to anti-VEGF treatment we established and validated two models of human pancreatic cancer cell lines resistant...