Lentiviral Transduction of CD34+ Cells Induces Genome-Wide Epigenetic Modifications

Volume: 7, Issue: 11, Pages: e48943 - e48943
Published: Nov 7, 2012
Abstract
Epigenetic modifications may occur during in vitro manipulations of stem cells but these effects have remained unexplored in the context of cell and gene therapy protocols. In an experimental model of ex vivo gene modification for hematopoietic gene therapy, human CD34(+) cells were cultured shortly in the presence of cytokines then with a gene transfer lentiviral vector (LV) expected to transduce cells but to have otherwise limited biological...
Paper Details
Title
Lentiviral Transduction of CD34+ Cells Induces Genome-Wide Epigenetic Modifications
Published Date
Nov 7, 2012
Journal
Volume
7
Issue
11
Pages
e48943 - e48943
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