p38α regulates SERCA2a function
Abstract
cAMP-dependent protein kinase (PKA) regulates the L-type calcium channel, the ryanodine receptor, and phospholamban (PLB) thereby increasing inotropy. Cardiac contractility is also regulated by p38 MAPK, which is a negative regulator of cardiac contractile function. The aim of this study was to identify the mechanism mediating the positive inotropic effect of p38 inhibition. Isolated adult and neonatal cardiomyocytes and perfused rat hearts were...
Paper Details
Title
p38α regulates SERCA2a function
Published Date
Feb 1, 2014
Volume
67
Pages
86 - 93
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