Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease
Volume: 5, Issue: 8, Pages: e1382 - e1382
Published: Aug 21, 2014
Abstract
Increasing evidence has shown the aberrant expression of inflammasome-related proteins in Alzheimer's disease (AD) brain; these proteins, including NLRP1 inflammasome, are implicated in the execution of inflammatory response and pyroptotic death. Although current data are associated NLRP1 genetic variants with AD, the involvement of NLRP1 inflammasome in AD pathogenesis is still unknown. Using APPswe/PS1dE9 transgenic mice, we found that...
Paper Details
Title
Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease
Published Date
Aug 21, 2014
Volume
5
Issue
8
Pages
e1382 - e1382
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