Predictors for Chronic Urinary Toxicity After the Treatment of Prostate Cancer With Adaptive Three-Dimensional Conformal Radiotherapy: Dose–Volume Analysis of a Phase II Dose-Escalation Study

Purpose To identify factors predictive for chronic urinary toxicity secondary to high-dose adaptive three-dimensional conformal radiation. Methods and Materials From 1999 to 2002, 331 consecutive patients with clinical Stage II–III prostate cancer were prospectively treated (median dose, 75.6 Gy). The bladder was contoured, and the bladder wall was defined as the outer 3 mm of the bladder solid volume. Toxicity was quantified according to the...