Application of an unusual ninhydrin-based reaction for the indirect chiral resolution of d,l-penicillamine
Abstract
An unusual reaction involving ninhydrin and aminothiols was exploited to set an indirect method for the chiral recognition of stereoisomers of penicillamine. Separation of diastereoisomers was achieved on a C18 column in isocratic mode by using a mixture of propionic acid (pH 3.0)/acetonitrile/water (10:10:80, v/v/v) as a mobile phase. Diastereoisomers were detected by a fluorescence detector in fairly short times (about 7 min) and with a good...
Paper Details
Title
Application of an unusual ninhydrin-based reaction for the indirect chiral resolution of d,l-penicillamine
Published Date
Sep 1, 2011
Journal
Volume
85
Issue
4
Pages
1783 - 1785
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